Linkam at AAPS 2019 PharmSci 360 in San Antonio, Texas: Spotlight on the Optical DSC450

The San Antonio Skyline. AAPS is held at the Henry B. Gonzalez convention centre, close to the 230 m tall Tower of the Americas

The San Antonio Skyline. AAPS is held at the Henry B. Gonzalez convention centre, close to the 230 m tall Tower of the Americas

Upper: San Antonio Riverwalk. Lower: The Alamo

Upper: San Antonio Riverwalk. Lower: The Alamo

We are excited to be attending this years AAPS (American Association of Pharmaceutical Scientists) PharmSci 360 conference from 3rd – 7th November in San Antonio, Texas. Alongside the conference we will be sure to visit the sites of San Antonio, such as the beautiful River Walk and the famous Alamo.

AAPS PharmSci is one of the top annual pharmaceutical conferences and brings together pharmacology, bioengineering, and medical development researchers from around the world. Linkam have a long history of providing temperature and environmental control analytical systems for biomedical applications, and we are happy to be a part of this community.

This year, we will be showcasing our Optical Differential Scanning Calorimeter, which enables the simultaneous measurement visualisation of thermal transition experiments for improved materials characterisation. The Optical DSC450 enables the user to measure melting behaviour and glass transitions of a wide range of substances whilst providing simultaneous image capture with the optional LINK Digital Imaging module.

The temperature of the DSC450 can be accurately controlled from -150 °C (with the optional LNP96) to +450 °C and the atmosphere of the stage can also be gas purged. It is often used to analyse pharmacological compositions and polymer-drug miscibility. The image data provides information of colour or morphological changes that can be correlated with temperature and phase transitions. Combining image and thermal analysis data can provide additional insights into the properties of the materials.

TASC (Thermal Analysis by Surface Characterisation) is a pioneering new image analysis technique which enables localised structural changes in samples to be tracked and quantified optically as they evolve with temperature. It has the unique ability to measure local transition temperatures allowing localised regions on a sample to be characterised. Combining the DSC450 with imaging and TASC provides a unique solution for the characterisation of the thermal properties of materials.

TASC enables precise measurement of structural changes through image analysis and can compliment DSC or work as a stand alone image structural analysis tool. Inset: DSC450

TASC enables precise measurement of structural changes through image analysis and can compliment DSC or work as a stand alone image structural analysis tool. Inset: DSC450

Peter Grocutt, R&D Director, commented: “Nearly all DSCs are large benchtop devices and are not primarily suited to microscope imaging. In addition, if cooling is required to lower temperatures (-150°C), large Dewars and complex cooling systems are required. The DSC450’s compact size lends itself to performing fast experiments and can be setup for cooling or heating in minutes. For cooling, it uses a small pump unit and a 3 litre Dewar, which once filled, can be used to cool the DSC450 immediately at the pre-set rate.

“The Thermal Analysis Sample Characterization software can reveal transitions that are difficult or impossible to measure easily by DSC alone, as smaller samples do not result in reduced sensitivity.”

The Optical DSC450 has recently been used to study phase transitions in pharmaceuticals, where the power of the complementary technique is particularly evident. The combination of optical microscopy and differential scanning calorimetry delivers increased sensitivity for detecting subtle characteristics such as solid-solid transitions.

Combining the DSC450 with spectroscopic techniques such as Raman and FTIR provide an ideal solution for the study of molecular changes such as Polymorphism.

To learn more about Linkam and its approach to the development of temperature stages for sample characterisation, contact us via info@linkam.co.uk.

If you are attending AAPS come to booth 1054 to talk to one of our specialists about the DSC, any of our other devices, or a customised system.

Related Content: