June’s Paper of the Month by Elie et al. focused on the role of a neuronal protein, Tau, and its link to two major cytoskeletal proteins: actin and microtubules.
These cytoskeletal filaments have a well-established dynamic and synergistic relationship in terms of cellular growth, division and movement. However the molecular basis governing this synergy remains poorly understood, although several proteins have been identified as potential ‘linkers’ between actin and microtubules. As they play a crucial role in cellular function, determining the mechanics of their relationship is fundamental in understanding cellular irregularities and pathologies.