Linkam stage in Antarctica

Pteropod Limacina helicina antarctica. Photo taken by the Hofmann Group, using a Wild M37 stereomicroscope and Linkam PE120 stage

Pteropod Limacina helicina antarctica. Photo taken by the Hofmann Group, using a Wild M37 stereomicroscope and Linkam PE120 stage

A team from the Hofmann Lab at the University of California, Santa Barbara, are studying the impacts of ocean acidification in calcifying marine invertebrates such as the pteropod Limacina helicina antarctica (pictured).

The team are based at the McCurdo research station in Antarctica, and have been using the Linkam PE120 stage to observe samples both at ambient temperature and at -5°C.

Read more on their research here

 

Linkam Press Releases October/November 2015

  A post doctorate research associate from Professor Rachel Williams' group at the University of Liverpool uses the Linkam TST350 stage at room temperature to characterise novel polymer materials

 

A post doctorate research associate from Professor Rachel Williams' group at the University of Liverpool uses the Linkam TST350 stage at room temperature to characterise novel polymer materials

9th October 2015 

Temperature Controlled Stage used in the Characterisation of Novel Electrolytes for more Efficient and less Volatile Fuel Cells

Linkam Scientific Instruments report on the use of their temperature controlled stages in the study of the novel electrolytes that can be used in fuel cells. This work was carried out at the Katholic University of Leuven in Belgium. 

27th October 2015

Tensile Stage Used to Assist with the Development of New Materials that Address Eye Healthcare in the Ageing Population 

Linkam Scientific Instruments report on the use of their tensile temperature controlled stage to develop and characterise novel materials that address the growing burden of eye healthcare in an ageing population. This work is being carried out at the University of Liverpool in the research group of Professor Rachel Williams.

4th November 2015 

Linkam stages in use in the Wolfson Bioimaging Facility at the University of Bristol as part of the endocytic sorting research of Dr Paul Verkade

Linkam Scientific Instruments report on the use of their temperature controlled stages applied to CLEM and fluorescence microscopy to assist in endocytic sorting in the School of Biochemistry at the University of Bristol.

 

Freeze Drying Training Course

We are pleased to be involved with the Freeze Drying Training Course ‘Lyophilisation: Practical Applications Utilising Latest Equipment’ at the Hooke College of Applied Sciences, running from 3rd-5th November.

This course covers aspects of freeze drying as it relates to the pharmaceutical, biological and food industries. These topics will first be discussed in a classroom setting and then put into practise in an onsite laboratory. Attendees will get hands-on experience with the Linkam FDCS196 freeze-drying cryo-stage.

Details and registration

The Linkam FDCS196 freeze drying system provides the ability to quickly and accurately determine collapse and eutectic temperature and intricately investigate freeze dried structure of complex samples.

Linkam Scientific introduce students to the CMS196 cryo-CLEM stage at the Francis Crick Institute

Towards the end of September we attended the UK’s first Correlative Light and Electron Microscopy (CLEM) interactive workshop. This was held at the prestigious Francis Crick Institute, in London, and will take place in alternate years with the European EMBO CLEM course in Bristol.

The course was fully booked with eight participants from eight different institutes in the UK working in pairs throughout the week to learn different CLEM workflows. The Linkam CMS196 Cryo-Correlative stage was used during the workshop so students could get practical experience of the system and see how it fits into the Cryo-CLEM workflow.

Above is a picture of mouse embryonic fibroblast (MEF) cells, prepared by PhD student Patricia Goggin and captured by Linkam's Michael Schwertner during the ‘correlative cryo-fluorescence leading to cryo-electron tomography or cryo soft x-ray tomography’ practical. This cryofluorescence image shows the cell nuclei in blue, mitochondria in green and filamentous actin in red. 

We had a great time showing off some of the features of our cyro-CLEM stage whilst also continuing to learn about some of its applications, and our thanks go to everyone involved, especially Dr Marie-Charlotte Domart, Dr Raffa Carzaniga, Dr Lucy Collinson and Dr Paul Verkade.

Read more here

Freeze Drying Webinar

 

On Thursday 1st October Linkam distributors The McCrone Group are running a free webinar on 'Thermal Characterization as Part of an Empirical Process for Developing Optimized Formulations and Lyophilization Cycles'.

The Webinar, presented by Dr Jeff Schwegman and McCrone technical sales representative Ruben Neiblas, introduces a well-defined process for taking an empirical approach to designing formulations, and the lyophilization cycles used to dry them.

Details and registration

The webinar preludes a course entitled ‘Lyophilization: Practical Applications Utilizing Latest Equipment’, featuring the Linkam FDCS196 freeze-drying cryo stage. This will take place from the 3rd-5th November.

The Linkam FDCS196 freeze drying system provides the ability to quickly and accurately determine collapse and eutectic temperature and intricately investigate freeze dried structure of complex samples.

 

Linkam supporting Correlative Light and Electron Microscopy Workshop at Francis Crick Institute

Linkam will be supporting the first UK hands-on workshop on ‘Correlative Light and Electron Microscopy', being held at the Francis Crick Institute in London from September 21st to 25th.

The workshop is organised by Raffa Carzaniga, Lucy Collinson and Paul Verkade, and will take place in alternate years with the European EMBO CLEM course in Bristol (next course in July 2016), enabling us to train more of the UK community in a wide range of CLEM techniques. The workshop will include detailed hands-on tutorials for 8-10 participants organised into groups of 2 people per tutor to maximise contact time, covering high pressure freezing and freeze substitution; preservation of fluorescence in-resin for integrated microscopy; plunge freezing, cryofluorescence and cryoEM; Tokuyasu cryosectioning and immunolabelling for correlative experiments; and 3D CLEM using Serial Block Face SEM.

The Linkam CMS196 Cryo Correlative stage will be used during the workshop so students will be able to get practical experience of the system and see how it fits into the Cryo-CLEM workflow. 

Introducing the DSC600 VISTA system at NATAS 2015

We will be attending the North American Thermal Analysis Conference (NATAS) from the 10th-13th August, to present our new DSC600 VISTA system.

We have worked in partnership with Cyversa to create VISTA - a revolutionary thermal technique that will provide Characterization Scientists with a powerful new tool for analysing materials.

Linkam’s Imaging Station is at the heart of the VISTA system and when combined with the new DSC600 VISTA hot stage, enables images of the sample to be simultaneously captured during an experiment. Thermal Analysis Sample Characterization software (TASC) from Cyversa generates curves based on the reflected light signal, to show changes in sample features that occurred during the experiment.

While DSC and TASC are complementary, TASC can reveal transitions that are difficult or impossible to measure easily by DSC, and sensitivity is not reduced with smaller samples and lower heating rates as is the case with DSC.  

A recent article in American Laboratory further discusses the advantages of this technique, with specific reference to its application in the analysis of polymer blends for drug delivery.

TASC can be used with any of our thermal stages, from the standard THMS heating-cooling stage, to the Tensile and Shear stages. TASC inventor Professor Mike Reading will be present at NATAS and available to discuss how TASC can benefit your application.

We hope to see you there!

New Dynamic Humidity Control -RH95, no need for costly dry air supply!

The new Linkam Humidity Controller is our latest instrument to add yet further sample control and is once again developed by in depth feedback of many Linkam stage users.

The RH95 quickly controls humidity inside a linkam stage or any other sealed chamber up to a volume of 2000cc from 5 to 90%.  

Unlike other humidity systems, no costly dry air supply is required. Ambient air is dried through a specially designed automatic recycling dessicant system and so can be left controlling humidity for months at a time.

Rather than simply monitoring the humidity of the air supplied to the chamber we also place a sensor inside the chamber to create a feedback loop to the controller.

Contact us for more info

VISTA - A visual approach to materials characterisation

Seeing is believing! VISTA offers a new approach to thermal analysis by combining standard thermal analysis techniques with image analysis. 

Linkam’s Imaging Station is at the heart of the VISTA system and when combined with their new DSC600 VISTA hot stage, enables images of the sample to be simultaneously captured during an experiment. An image processing software module from Cyversa analyses these images to produce thermal curves based upon the changes in sample features observed during the experiment.