August's Paper of the Month

Thermophotovoltaics (TPV) is the conversion of thermal radiation released by a thermal emitter into electricity by means of a photovoltaic cell.

Power generation with a TPV system can be envisaged for almost any process and an absence of moving parts has the advantage of low maintenance costs. Thermal emission scales with temperature to a power of 4, meaning temperature above 1000 °C is required to generate significant power in such systems.

However, the wide spectral width of thermal radiation limits the efficiency of TPV conversion as only part of the spectrum is accepted by the photovoltaic cell. August’s Paper of the Month by Dyachenko et al., attempts to solve the TPV efficiency problem by designing and using a unique refractory metamaterial as an emitter instead of the traditional structural resonances.

Read more... 


Linkam in France: deuxième partie

The Gateway College bridge crosses the river Rhone  in Lyon.

The Gateway College bridge crosses the river Rhone  in Lyon.

Renowned for its exquisite food, rich cultural history and annual Festival of Lights, Lyon is one of France’s most visited cities. We are excited to announce Linkam will be heading there soon. 

The European Microscopy Congress will take place at the Lyon Convention Centre from the 28th August to the 2nd September. This will be Linkam’s second trip to France this year after the highly successful European Materials Research Society spring meeting.

With over 2000 guests, several hundred guest speakers, specialised workshops and symposia covering the life sciences, instrumentation and methods and materials science, EMC will be an excellent platform to showcase our stages. 

We’ll be taking along the tensile TST350, cryo-correlative CMS196, dual pan DSC, humidity system RH95 and one of our electrical probe stages, the LTS420 E-PB4

Come over to booth 3 to discuss how our stages can enhance your sample characterisation needs - we look forward to seeing you there.


July's Paper of the Month

Cryo-preserved cells are vulnerable to Ice Recrystallisation (IR). This is the formation of large ice crystals at the expense of smaller crystals and occurs during repeated freezing and thawing events. These crystals can rupture cell membranes and thus post-thaw cell numbers are often much lower than the number frozen.  IR is a major factor in causing primary graft failure in transplantation patients. 

July’s Paper of the Month by Briard et al., discovered a novel class of carbohydrate derivatives with ice recrystallisation inhibiting properties that retain potency at lower glycerol percentages. The new ice recrystallisation inhibitors (IRIs) are of low molecular weight making them ideal additives to cellular systems. Briard et al., tested the ability of these molecules to reduce ice recrystallisation and ultimately improve the survival rate of cryo-preserved cells.


June's Paper of the Month

June’s Paper of the Month by Elie et al. focused on the role of a neuronal protein, Tau, and its link to two major cytoskeletal proteins: actin and microtubules. 

These cytoskeletal filaments have a well-established dynamic and synergistic relationship in terms of cellular growth, division and movement. However the molecular basis governing this synergy remains poorly understood, although several proteins have been identified as potential ‘linkers’ between actin and microtubules. As they play a crucial role in cellular function, determining the mechanics of their relationship is fundamental in understanding cellular irregularities and pathologies.



May's Paper of the Month

May’s ‘Paper of the Month’ is a collaboration between a number of different laboratories and Institutes: the Max Planck Institute of Colloids and Interfaces, Nanyang Technological University, Massachusetts Institute of Technology and the Wyss Institute for Biologically Inspired Engineering.

Their paper ‘Multi-scale thermal stability of a hard thermoplastic protein-based material’ determined the thermal properties of a potentially novel and sustainable biopolymer to replace the unsustainable petrochemical polymers we rely so heavily on today. 

The search is on to find alternatives to petrochemical based polymers which can be used to synthesize thermoplastics. But it is challenging because not many biopolymers have the chemical properties required to replace thermoplastics. Even when such properties are induced through chemical processing, the biopolymers often lose the integrity of their physical nature. However, one exception may be Sucker Ring Teeth (SRT), made of a protein called Suckerin, which is found in the tentacles of squid and cuttlefish. 


Lighting the Way

Next week, Linkam will be taking a short trip to Didcot, in Oxfordshire, for the ‘UK Bio-XFEL Single Particle Imaging Workshop’ hosted by Diamond Light Source (the UK’s national synchrotron science facility). The event will take place on the 2nd and 3rd June in the Pickavance Theatre at the Science and Technology Facilities Council, at Harwell. 

The two day workshop is aimed at the life science sector, mainly biological and biomedical. X-ray Free Electron Lasers (X-FEL) have been used by biological researchers in x-ray crystallography, but another application - Single Particle Imaging (SPI) - is gaining rapid attention due to its ability to determine 3D structures without crystallisation. The workshop gives voice to field experts and focuses on encouraging and demonstrating the use of X-FEL for SPI to laboratory scientists.

Come over to our stand to see our cryo-correlative CMS196, the tensile TST350 and the high temperature TS1500.

We look forward to seeing you there and discussing your sample characterisation needs!


Paper of the Month

April’s ‘Paper of the Month’ comes from the Institute of Light and Matter (Université Claude Bernard Lyon 1 and French National Centre for Scientific Research (CNRS)), where the project was conceived by Professor Frédéric Caupin.

Rock minerals almost always contain Fluid Inclusions (FIs). These inclusions contain snippets of atmospheric and fluid data trapped at the time of the rock’s formation and thus have been used in the past as proxies to estimate the variability of the Earth’s surface temperature.
These fluid inclusions – upon cooling – can nucleate bubbles within the rock and it is these bubbles that can be studied to determine the ambient temperature at the time the fluid was trapped. 

However this relies on the presence of the nucleation bubble, which is not always there. In this study, Professor Caupin’s group created a new approach which bypasses the need for this nucleation bubble. Their method follows the interaction between laser light and fluid droplets – Raman spectroscopy and Brillouin microscopy – from which paleothermometry data can be drawn.

This approach may provide a novel route to understanding the earth’s climatic history. 


Paper of the Month

   Atomic Force Microscopy optical image of black phosphorous. (Image from Su & Zhang, 2015)


Atomic Force Microscopy optical image of black phosphorous. (Image from Su & Zhang, 2015)

March’s ‘Paper of the Month’ comes from Dr Yong Zhang and Dr Liqin Su at the University of North Carolina Charlotte (UNCC).

In their paper “Temperature coefficients of phonon frequencies and thermal conductivity in black phosphorous layers” (Applied Physics Letters, 2015), Zhang and Su investigate the vibrational properties and electron-phonon interactions of black phosphorous, as well as how epitaxial or supporting substrates can impact the properties of a 2D material which is often presumed to have weak bonding with the substrate.

Black phosphorous is a particularly promising material due to its layer-dependant band gap, meaning it can function as a semi-conductor – essentially, it can be switched on and off. Its application in new nanotechnologies could give rise to a range of high performance electronic and optoelectronic devices.

Read more…


New Video: Cryo-CLEM grid mapping

CMS196M automated mapping of an EM grid at high resolution.  

The cryo-correlative stage, CMS196M can automatically map EM grids at high resolution making it a simple matter to find and record the co-ordinates of the key areas of interest in your sample. The video above shows how easy it is to set up the CMS196M with the new LINK software and create high resolutions maps of the full EM grid.

Freeze Drying Focus Group

pharmaceutics conference Linkam news.png

This March, the Friedrich-Alexander University’s ‘Freeze Drying Focus Group’ will be presented in English for the first time.

The 1 day seminar includes sessions on:

  • The Basic Principles of Freeze Drying
  • The ‘World of Thermal Analysis’ Using Freeze Dry Microscopy — which will be co-presented by Linkam’s Dr Michael Schwertner
  • Defining the quality of a Freeze Dried product
  • Instrument Demonstration and Laboratory Practice
  • Designing a Freeze Drying Cycle
  • and New insights in Freeze Drying of Co-Solvent Systems.

This is the University's Department of Pharmaceutics’ 11th Annual Seminar, and it is an event that has always proved very popular in the past.  

The seminar brings together people from academia, the pharmaceutical industry and vendors & suppliers of equipment to initiate sound scientific discussions in the field of freeze drying and also provides updates on the latest trends and research interests in this field.

Our FDCS196 Freeze Drying Cryo Stage will be on show throughout the day. 

More information and details on how to register for the seminar can be found here.