Pharmaceutical Applications

Linkam has been developing sample characterisation solutions to help push the boundaries of science for over 30 years.

Understanding the thermal properties of materials is essential in many areas of the pharmaceutical industry. The precise and accurate control of the temperature of your sample has been further enhanced to enable more detailed characterisation of materials with the introduction of systems such as the new optical DSC, humidity control and lyophilisation systems. Linkam has long worked with the pharmaceutical industry to develop solutions for some of the key problems from drug development and formulation to manufacturing, QA, packaging and storage.

We have solutions for lyophilisation, thermoanalysis, dissolution studies, shelf-life testing and many more.

Linkam systems are compatible with light microscopy and spectroscopy techniques including Raman, FT-IR and X-ray.

Related Products

Published Papers

Research Papers List
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research paper, open source
pharma, Imaging Station
The Effects of Solid Particle Containing Inks on the Printing Quality of Porous Pharmaceutical Structures Fabricated by 3D Semi-Solid Extrusion Printing
research paper, open source
pharma, Imaging Station
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research paper, open source
pharma, Imaging Station
eye.png
research paper
materials, tensile stage, drug delivery, hydrogel, pharma, antimicrobial, cornea
A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens
research paper
materials, tensile stage, drug delivery, hydrogel, pharma, antimicrobial, cornea
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research paper
materials, tensile stage, drug delivery, hydrogel, pharma, antimicrobial, cornea
research paper, open source
pharma, DSC
Hot stage microscopy and its applications in pharmaceutical characterization
research paper, open source
pharma, DSC
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research paper, open source
pharma, DSC
research paper
pharma, peltier
Supramolecular synthesis and thermochemical investigations of pharmaceutical inorganic isoniazid salts
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pharma, peltier
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pharma, peltier
tablets.jpg
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pharma, FTIR600, raman
Phase transitions in secnidazole: Thermal stability and polymorphism studied by X-ray powder diffraction, thermal analysis and vibrational spectroscopy
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pharma, FTIR600, raman
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pharma, FTIR600, raman
lab.jpg
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pharma, thms, thms600
Process control of a dropwise additive manufacturing system for pharmaceuticals using polynomial chaos expansion based surrogate model
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pharma, thms, thms600
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research paper
pharma, thms, thms600
processing.jpg
research paper
pharma, FDCS196
Mannitol/l-Arginine-Based Formulation Systems for Freeze Drying of Protein Pharmaceuticals: Effect of the l-Arginine Counter Ion and Formulation Composition on the Formulation Properties...
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pharma, FDCS196
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pharma, FDCS196
processing.jpg
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pharma, thms, thms600
Preparation of pharmaceutical cocrystal formulations via melt mixing technique: A thermodynamic perspective
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pharma, thms, thms600
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pharma, thms, thms600
pills.jpg
research paper
pharma, LTS
Multiple approaches to pharmaceutical polymorphism investigation—A case study
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pharma, LTS
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pharma, LTS
research paper
pharma, thms, thms600-ps
“Predicting” Polymorphs of Pharmaceuticals Using Hydrogen Bond Propensities: Probenecid and Its Two Single‐Crystal‐to‐Single‐Crystal Phase Transitions
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pharma, thms, thms600-ps
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research paper
pharma, thms, thms600-ps

Application Notes

Application Notes
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Application Note
imaging, ftir600, pharma
Studying a New Polymorph of Metacetamol with FTIR
Application Note
imaging, ftir600, pharma

The FTIR600 stage is used to measure IR spectra at variable temperatures, and transformations between polymorphs followed in situ by heating and cooling the samples in the chamber.

Application Note
imaging, ftir600, pharma
Application Note
fdcs, pharma, life science, freeze-drying, fdcs196
Unravelling the complexities of freeze-drying pharmaceuticals with advanced microscopy techniques
Application Note
fdcs, pharma, life science, freeze-drying, fdcs196

Linkam’s FDCS196 is used by researchers at NIBSC and the University of Strathclyde to predict freeze-drying conditions for liposome-cryoprotectant mixtures (drug delivery systems), using light microscopy with a cryostage.

Application Note
fdcs, pharma, life science, freeze-drying, fdcs196
DSC polymer interactions.png
Application Note
DSC, pharma
Investigating drug-polymer interactions using optical DSC
Application Note
DSC, pharma

Researchers from the University of Hertfordshire’s School of Life and Medical Sciences collaborated with Linkam to provide an in-depth analysis into how the optical DSC450 and TASC can be used to characterise drug-polymer-excipient systems for pharmaceutical applications. Read the full case study here.

Application Note
DSC, pharma
Annotation 2020-05-29 143033.png
Application Note
DSC, TASC, pharma
A Novel Thermal Microscopic Imaging Tool for Rapid Pre-Formulation Screening of Solid Dispersions
Application Note
DSC, TASC, pharma

See how TASC can be used as a rapid and inexpensive screening method during the preformulation stage of solid dispersion based pharmaceutical products.

Application Note
DSC, TASC, pharma
crystillisation.jpg
Application Note
DSC, TASC, polymers, imaging, pharm, pharma
Studying Phase Transitions in Pharmaceuticals
Application Note
DSC, TASC, polymers, imaging, pharm, pharma

Polymorphism in pharmaceutical solids has great implications on both the processing and the performance of solid pharmaceutical products. This app note details work from the School of Pharmacy at UCL using TASC with our DSC450 to characterise polymorphic transitions in the pharmaceutical active compound flufenamic acid .

Application Note
DSC, TASC, polymers, imaging, pharm, pharma

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