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Freeze Drying microscope stage system
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Freeze Drying Microscope System

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Features and Benefits

The FDCS196 is Linkam's highly successful freeze drying cryo stage used by leading research scientists within the pharmaceutical and food science industries.

Using the FDCS and light microscopy techniques such as phase contrast and polarized light, it is now possible to accurately determine collapse and eutectic temperature and intricately investigate freeze dried structure of complex samples.

Both stage pressure and temperature can be accurately controlled and programmed to simulate industrial procedures and determine ideal drying parameters.

Temperature is measured to 0.01°C by a Pt100 resistor mounted close to the sample and controlled to 0.1°C even down to pressures as low as 10-3mbar.

Chamber pressure is monitored by a pirani gauge mounted directly on the stage and shows the stage to hold perfectly uniform vacuum even when the XY manipulators are used to follow the drying front moving across the sample.

The pressure can now be controlled by the new Linkam VC94 motorized valve. Simply type a chamber pressure and observe the new stable vacuum in less than a minute.

A graph of temperature against time also shows the plot of the chamber pressure throughout the experiment.

Using the Linksys 32-DV or AV software it is possible to capture images of the freeze drying run with all the experimental data ( temperature, time, date, pressure, magnification) inlaid in each image.

These images can be viewed in a gallery or as an AVI movie with captions containing all the data scrolled underneath the viewing window.

With a temperature range down to -196C, Ultra low temperature eutectics can be investigated with the FDCS system, not possible with peltier controlled systems.

See FDCS image Gallery

Download Product Data for Freeze Drying System

linkam freeze drying system

motorized vacuum control

Motorized Vacuum Control

freeze drying front

See Image gallery

FDCS Specifications

  • Temperature range -196° to 125°C
  • Up to 130°C/min heating/cooling
  • Temperature stability <0.1°C
  • 16 mm X,Y sample manipulation
  • Sample area 22 mm diameter
  • Vacuum tight sample chamber to 10-3 mbar even with XY manipulation.
  • Clamps directly to the microscope substage for stability
  • 100Ohm platinum resistor sensor. 1/10th Din Class A to 0.1°C
  • Light aperture - 1.3mm Ø
  • Silver heating block for high thermal conductivity
  • Direct injection of the coolant into the silver block
  • Single ultra thin lid window - 0.3mm
  • Objective lens working distance - 4.5mm
  • Condenser lens minimum working distance 12.5mm
  • Range of condenser extension lenses available
  • Can be used with all microscope techniques
  • Suitable for Confocal, Laser Raman, IR and X-ray
  • Stage body size - 137 x 92 x 22 mm

VC94 Motorized Vacuum Control

The VC94 consists of a software controlled motorized valve that will control the vacuum pressure inside the freeze drying chamber of the FDCS, enabling the user to closely investigate the effects of pressure on sample collapse.

Simply type the value of vacuum pressure you want in either mbar or Torr and click the button. The valve will change the vacuum to the new stabilized value in less than a minute.

Vacuum pressure will be plotted with temperature against time and can be saved for later analysis.

motorized valve

A Freeze Drying Cryostage system comes as a turn key package including:

FDCS196 cryostage

TMS94v Temperature Programmer with vacuum readout

LNP94/2 Liquid Nitrogen pump

FDG Pirani Vacuum Gauge

2xNW16 clamping rings

2xNW16 O-ring seals

LINKSYS 32 Temperature control software

Optional but Recommended:

L32OP-DV Digital Video Capture including Firewire camera

Stage clamps specific to microscope (Most Olympus, Nikon, Leica and Zeiss are compatible)

Condenser Extension Lens (Olympus, Nikon, Zeiss compatible, see Optical accessories)

Optional Vacuum Control.

VC94 motorized valve and controller (compatible with Edwards 1.5L Rotary pump)

In order to get highly resolved images, it is important to use a condenser extension lens. See Optical Accessories for more information

 

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