Cryo-Correlative Light Electron Microscopy

Cryo correlative light electron microscopy (cryo-CLEM) is a powerful technique that combines the advantages of cryo-fluorescence microscopy and cryo-electron microscopy to study biological samples in their near-native state. Cryo-CLEM allows researchers to identify and locate specific molecules of interest within the ultrastructure of cells or tissues, revealing the molecular mechanisms of life.