The FTIR600 stage is used to measure IR spectra at variable temperatures, and transformations between polymorphs followed in situ by heating and cooling the samples in the chamber.
Replicating the texture of meat in plant-based alternatives using Linkam’s Modular Force Stage (MFS).
Investigating drug-polymer interactions using optical DSC
Researchers from the University of Hertfordshire’s School of Life and Medical Sciences collaborated with Linkam to provide an in-depth analysis into how the optical DSC450 and TASC can be used to characterise drug-polymer-excipient systems for pharmaceutical applications. Read the full case study here.
Webinar: From Ancient Relics to Life on Mars: Temperature-Controlled Experiments for Materials Characterisation
In advance of the Mars landing on 18 February 2021, members of the Analytical Chemistry group at Universidad del País Vasco / Euskal Herriko Unibertsitatea (University of the Basque Country) in Leioa, Spain presented their research on how temperature controlled experiments (including Raman spectroscopy, X-ray fluorescence and XRD analysis) can be used to characterise geological materials ranging from historical artefacts from the Roman empire to regolith samples from Mars.
The importance of being small: miniaturisation of freeze drying equipment
Developmental activities for freeze-dried products are dictated by the limited availability and high cost of newly developed active compounds, and by Quality-by-Design requirements. Laboratory-scale freeze dryers used for formulation and process development show an excessive variety of designs and instrumentation concepts, making scale-up activities a challenge. The development of miniaturised equipment may provide enormous benefits in terms of development times and costs.
Researchers use Linkam stages to investigate how temperature-controlled microscopy enhances research of chemical processes in polar ice
Temperature-Controlled Fabrication of Functional Nanomaterials with High Surface Areas Using Linkam’s TS1500
Breaking new ground in thin film research with temperature-controlled ellipsometry.
Studies shed new light on phase transitions and laser-induced nucleation using Linkam’s THMS600.
Using Raman Spectroscopy to Probe the Degradation of Perovskite Thin Film Photovoltaic Devices
Using in situ characterisation approaches to study catalytic activity
Studying thermal dehydration of Lithium borohydrides via in situ Raman spectroscopy using Linkam’s CCR1000
Fragmentation Test Method for Adhesion Analysis of Coatings In Situ in a Microscope using Linkam’s Mechanical Testing System.
Researchers in Switzerland used Linkam’s mechanical testing system to study the mechanical integrity and adhesive properties of polymer coatings.
Geological Applications of Temperature Controlled Microscopy using Linkam’s MDS600
A Novel Thermal Microscopic Imaging Tool for Rapid Pre-Formulation Screening of Solid Dispersions
The Effect of Supercooling on Cryopreservation of Cells using Linkam’s FDCS196
Using FTIR spectroscopy to image large and multi-phase samples and monitor fast dynamic processes
Studying Phase Transitions in Pharmaceuticals using Linkam’s DSC450 in combination with TASC.
Polymorphism in pharmaceutical solids has great implications on both the processing and the performance of solid pharmaceutical products. This app note details work from the School of Pharmacy at UCL using TASC with our DSC450 to characterise polymorphic transitions in the pharmaceutical active compound flufenamic acid .
A Thermal Analysis Technique That Combines Differential Scanning Calorimetry and Light Microscopy
TASC is a powerful technique to gain structural phase information, similar to DSC, from a range of our temperature control stages including the DSC450 and THMS600. This article discusses the advantages of this technique, with specific reference to its application in the analysis of polymer blends for drug delivery.