Linkam’s FDCS196 is used by researchers at NIBSC and the University of Strathclyde to predict freeze-drying conditions for liposome-cryoprotectant mixtures (drug delivery systems), using light microscopy with a cryostage.
The importance of being small: miniaturisation of freeze drying equipment
Developmental activities for freeze-dried products are dictated by the limited availability and high cost of newly developed active compounds, and by Quality-by-Design requirements. Laboratory-scale freeze dryers used for formulation and process development show an excessive variety of designs and instrumentation concepts, making scale-up activities a challenge. The development of miniaturised equipment may provide enormous benefits in terms of development times and costs.
Temperature-controlled microscopy enhances research of chemical processes in polar ice
The polar regions of the Antarctic and the Arctic are indicators of the changing global climate, and there is a lot of research underway to investigate how changing conditions will affect the polar ecosystems and beyond. The Korean Polar Research Institute (KOPRI) uses Raman spectroscopy in combination with Linkam stages to study ice crystals and chemical processes in polar ice in order to better understand climate change.
The Effect of Supercooling on Cryopreservation of Cells
Cryo-Flourescence Mapping For Correlative Microscopy Of Biological Samples
Intracellular segregation processes in the endocytic system
Improved suppression of cancerous cells by regulating the toxicity of chemotherapy medication
Protein-Inspired Ice Recrystallization Inhibition
Researchers at the University of Warwick use the Linkam BCS196 to work at the interface of the organic and polymer chemistries with the life sciences, making use of modern polymer and organic methods to synthesise nano materials for various applications, including regenerative medicine, infectious disease and biotechnology.