3D printing pharmaceutical products opens the door to an exciting world of individually tailored drugs, unique for each patient. In this paper the drying process of single and multi-layered printed materials was monitored using the Linkam Imaging Station, monitoring changes in pore size as the 3D printed paracetamol was dried.
A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens
Hot stage microscopy and its applications in pharmaceutical characterization
Full article available per CC BY 4.0.
Kumar, A., Singh, P. & Nanda, A. Hot stage microscopy and its applications in pharmaceutical characterization. Appl. Microsc. 50, 12 (2020). DOI: 10.1186/s42649-020-00032-9
Supramolecular synthesis and thermochemical investigations of pharmaceutical inorganic isoniazid salts
Using one of Linkam’s Peltier stages, research performed hot stage microscopy measurements on inorganic salts for pharmaceutical applications.
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Phase transitions in secnidazole: Thermal stability and polymorphism studied by X-ray powder diffraction, thermal analysis and vibrational spectroscopy
Here, researchers use techniques such as Raman spectroscopy, X-ray powder diffraction and hot stage microscopy with Linkam’s FTIR600 to observe the dehydration process of the antimicrobial drug secnidazole, which aids quality control and development of solid pharmaceutical formulations.
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Process control of a dropwise additive manufacturing system for pharmaceuticals using polynomial chaos expansion based surrogate model
Mannitol/l-Arginine-Based Formulation Systems for Freeze Drying of Protein Pharmaceuticals: Effect of the l-Arginine Counter Ion and Formulation Composition on the Formulation Properties...
Preparation of pharmaceutical cocrystal formulations via melt mixing technique: A thermodynamic perspective
Multiple approaches to pharmaceutical polymorphism investigation—A case study
In this work, researchers use Linkam’s LTS350 (now LTS420) stage to characterise the physiochemical properties of a pharmaceutical solid compound in four different forms (anhydrous polymorphs (Forms I and II) and two monohydrates (Forms III and IV)) to evaluate its suitability for pharmaceutical development.
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“Predicting” Polymorphs of Pharmaceuticals Using Hydrogen Bond Propensities: Probenecid and Its Two Single‐Crystal‐to‐Single‐Crystal Phase Transitions
See how Linkam’s THMS600-PS and Imaging Station are used to screen polymorphs for pharmaceutical applications, using hot stage microscopy to analyse their crystal formation behaviour.
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